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Jason P. Gleghorn, Ph.D.

Postdoctoral Associate
Sibley School
of Mechanical & Aerospace Engineering

Project Web Pages:

Electrokinetic Transport in Cartilage and Tissue Engineered Scaffolds and Microfluidic Circulating Tumor Cell Capture

Email:

jpg38@cornell.edu

Address:

188 Rhodes Hall
Cornell University
Ithaca, NY 14853

Phone:

(607) 255-0975

Fax:

(607) 255-1222

 

 

Biography

Jason Gleghorn joined the Micro/Nanofluidics Laboratory in December of 2007 after completing a Ph.D. in Biomedical Engineering from Cornell University. Jason is a member of the Biomedical Engineering Society, Tau Beta Pi, Pi Tau Sigma, and Order of Omega.


Current Projects

Current projects include the development of microdevices for the optimized capture of circulating prostate tumor cells from blood through manipulation of the fluidic environment and surface conjugation of PSMA specific antibodies. In addition, other projects utilize photo-polymerization technologies and manipulation of the electrokinetic microenvironment to investigate mamalian cell responses for tissue engineering applications.

 

Education

  • Ph.D. 2008, Cornell University, Biomedical Engineering
  • B.S. 2000, Worcester Polytechnic Institute, Mechanical Engineering, with Honors

 

Honors & Awards

  • NASA GSRP Fellowship (2004-2007)
  • Poster Award: First Place, Cornell BioExpo (2007)
  • BMES Conference Travel Grant (2004, 2005, 2006)
  • Cornell Conference Travel Grant (2005, 2006)
  • Poster Award: First Place, Cornell Engineering Research Showcase (2006)
  • Poster Award: First Place, ABRCMS Conference (2006)
  • Poster Award: Third Place, Cornell BioExpo (2005)
  • Robert H. Goddard Fellow (2001-2002)

 

Invited Presentations

  •  

BG Hawkins, JP Gleghorn, S Kondapalli, BJ Kirby. Sorting, Capture, and Concentration of Cells in Microdevices: Geometric Design. Joint Meeting of the International Society of Biorheology and international Society of Clinical Hemorheology; State College, PA: July 2008.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar. Frictional Properteis of Engineered Cartilaginous Tissues in Boundary Lubrication. European Cells and Materials 12, Supplement 1:47. European Cells and Materials Meeting; Davos, Switzerland: July 2006.

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JP Gleghorn, Principles of Tissue Engineering; NYSC 3 day short course, National Youth Science Foundation, Charleston, WV: July 2005.

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JP Gleghorn, Fundamentals of Bioengineering; NYSC 3 day short course, National Youth Science Foundation, Charleston, WV: June 2004.

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JP Gleghorn, LJ Bonassar, Joint Lubrication and the Role of Lubricin, Cornell Veterinary Medicine Grand Rounds, Ithaca, NY: March 2004.

 

Peer-Reviewed Publications

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JP Gleghorn, SB Doty, RF Warren, TM Wright, SA Maher, LJ Bonassar. Analysis of frictional behavior and changes in morphology resulting from cartilage articulation with porous polyurethane foams. Journal of Orthopaedic Research, epub ahead of print, 2010.

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JP Gleghorn, ED Pratt, D Denning, H Liu, NH Bander, ST Tagawa, DM Nanus, PA Giannakakou, BJ Kirby. Capture of Circulating Tumor Cells from Whole Blood of Prostate Cancer Patients Using Geometrically Enhanced Differential Immunocapture (GEDI) and a Prostate-Specific Antibody. Lab on a Chip, 10(1):27-9, 2010.

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CR Flannery, R Zollner, C Corcoran, ARC Jones, A Root, MA Rivera-Bermudez, T Blanchet, JP Gleghorn, LJ Bonassar, AM Bendele, EA Morris, SS Glasson. Prevention of Cartilage Degeneration in a Rat Model of Osteoarthritis by Intraarticular Treatment with Recombinant Lubricin. Arthritis & Rheumatism, 60(3):840-7, 2009.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar, Alteration of Articular Cartilage Frictional Properties by TGF-beta, IL-1beta, and Oncostatin M. Arthritis & Rheumatism, 60(2):440-9, 2009.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar, Boundary Mode Lubrication of Articular Cartilage by Recombinant Human Lubricin. Journal of Orthopaedic Research, 27(6):771-7, 2009.

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ARC Jones, S Chen, D Chai, AL Stevens, JP Gleghorn, LJ Bonassar, AJ Grodzinsky, CR Flannery, Modulation of Lubricin Biosynthesis and Tissue Surface Properties Following Cartilage Mechanical Injury. Arthritis & Rheumatism, 60(1):133-42,2009.

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MR Buckley, JP Gleghorn, LJ Bonassar, I Cohen, Mapping the Depth Dependence of Shear Properties in Articular Cartilage. Journal of Biomechanics, 41(11):2430-7, 2008.

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JJ Ballyns, JP Gleghorn, V Niebrzydowski, JJ Rawlinson, H Potter, SA Maher, T Wright, LJ Bonassar, Image Guided Engineering of Anatomically Shaped Implants via MRI and Micro-CT. Tissue Engineering Part A, 14(7):1195-202, 2008.

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JP Gleghorn, LJ Bonassar, Lubrication Mode Analysis of Articular Cartilage Using Stribeck Surfaces. Journal of Biomechanics, 41(9):1910-8, 2008.

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NW Choi, M Cabodi, B Held, JP Gleghorn, LJ Bonassar, AD Stroock, Microfluidic Scaffold for Three-Dimensional Cell Culture. Nature Materials, 6(11):908-15, 2007.

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JP Gleghorn, CSD Lee, M Cabodi, AD Stroock, LJ Bonassar, Adhesive Properties of Laminated Alginate Gels for Tissue Engineering of Layered Structures. Journal of Biomedical Materials Research Part A, 85(3):611-8, 2007.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar, Frictional Properties of Engineered Cartilaginous Tissues. European Cells & Materials Journal, 14:20-8; discussion 28-9, 2007.

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CSD Lee, JP Gleghorn, NW Choi, M Cabodi, AD Stroock, LJ Bonassar, Integration of Layered Chondrocyte-Seeded Alginate Hydrogel Scaffolds. Biomaterials, 28:2987-93, 2007.

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ARC Jones, JP Gleghorn, CE Hughes, LJ Fitz, R Zollner, SD Wainwright, B Caterson, EA Morris, LJ Bonassar, CR Flannery, Binding and Localization of Recombinant Lubricin to Articular Cartilage Surfaces. Journal of Orthopaedic Research, 25(3):283-92, 2007.

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JP Gleghorn, JE Miller, Roles for Students in Instruction and Assessment in Introductory Anatomy and Physiology Courses. Journal of Student Centered Learning, 3(1):7-12, 2006.

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M Cabodi, NW Choi, JP Gleghorn, CSD Lee, LJ Bonassar, AD Stroock. A Microfluidic Scaffold. Journal of the American Chemical Society, 127(40):13788-89, 2005.

 

Conference Presentations (selected from 34 total)

  •  

JP Gleghorn, ED Pratt, MS Loftus, BE Levy, NH Bander, DM Nanus, PA Giannakakou, BJ Kirby. High Efficiency Capture of Circulating Tumor Cells from Patient Blood Using geometrically Enhanced Differential Immunocapture. MicroTAS 2009 - Podium Presentation.

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NW Choi, M Cabodi, B Held, JP Gleghorn, H Dvora, KY Park, LJ Bonassar, AD Stroock. Microfluidic Scaffold for Three-Dimensional Cell Culture and Oxygen Sensing. AIChE 2007.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar. Effect of Cytokines on Lubricin Production and Frictional Properties of Articular Cartilage. BMES 2007.

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JP Gleghorn, SB Doty, TM Wright, SA Maher, LJ Bonassar. Frictional Analysis and Tissue Changes in Interfaces of Cartilage and Joint Reconstruction Materials. BMES 2007 - Podium Presentation.

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MR Buckley, JP Gleghorn, I Cohen, LJ Bonassar (2007) Depth Dependance of Shear Properties in Articular Cartilage. Trans Orthop Res Soc 32:102. 53rd Orthopaedic Research Society Meeting: San Diego, CA.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar (2007) Role of Electrostatic Interactions in the Lubrication of Articular Cartilage by Recombinant Lubricin. Trans Orthop Res Soc 32:550. 53rd Orthopaedic Research Society Meeting: San Diego, CA.

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JP Gleghorn, LJ Bonassar (2007) Mapping of Cartilage Lubrication Modes Using Stribeck Analysis. Trans Orthop Res Soc 32:613. 53rd Orthopaedic Research Society Meeting: San Diego, CA.

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JP Gleghorn, ARC Jones, CR Flannery, LJ Bonassar (2007) Boundary Lubrication of Tissue Engineered Cartilages by Recombinant Lubricin. Trans Orthop Res Soc 32:1508. 53rd Orthopaedic Research Society Meeting: San Diego, CA.

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A Ippolito, JP Gleghorn, SA Maher, D Carlton, TM Wright, R Warren, LJ Bonassar (2007) Tissue Engineering of Meniscus Using Human Fibrochondrocytes. Trans Orthop Res Soc 32:1532. 53rd Orthopaedic Research Society Meeting: San Diego, CA.