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Electrokinetic Properties of Microfluidic Substrates
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Funding: DOE, Lockheed Martin, Cornell, ACS-PRF
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Among the unique properties of microfluidic
devices is the ability to move liquids via
electroosmosis.
When the solid-liquid interface acquires a
surface charge, an electrical double layer
is formed as ions
in the electrolyte solution align preferentially
based on their charge. When this occurs, an electric
field applied parallel to the wall will induce fluid flow.
Modeling and predicting the electrokinetic
properties of microfluidic substrates that lead
to electroosmosis is inherently difficult.
The surface charges are a function of chemical
reactions and adsorption/desorption processes, many of which
are not fully understood. Further, the
electrical double layer is often nanometers
thick, and bulk
fluid properties typically do not apply
close to the wall, where the highest charge density (and
therefore most of the action) resides.
Our work on the electrokinetic properties of
microfluidic substrates includes (1) experimental
characterization
of interface properties, (2) chemical
modification of interface properties,
and (3) analytical and numerical modeling
of double layer phenomena.
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Archival Publications |
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Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices,"
Cambridge University Press, 2010.
click here for html version|
Cambridge University Press
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Wilkes JO , with Birmingham SG,
Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD,"
Prentice-Hall, 2005.
click here to go to text webpage
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Barbati AC,
Kirby BJ,
"Soft Diffuse Interfaces in Electrokinetics - Theory and experiment
for transport in charged diffuse layers", Soft Matter, 8:10598-10613, 2012.
doi
pdf
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Connelly JT,
Kondapalli S,
Skoupi M,
Parker JSL,
Kirby BJ,
Baeumner AJ
"Micro total analysis system for virus detection:microfluidic pre-concentration coupled to liposome-based detection,"
Analytical and Bioanalytical Chemistry, Volume 402, Number 1, 315-323, 2012.
doi
pdf
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Kondapalli S,
Connelly JT,
Baeumner AJ,
Kirby BJ
"Integrated microfluidic preconcentrator and immunobiosensor,"
Microfluidics and Nanofluidics, Volume 11, Number 5, 537-544, 2011.
doi
pdf
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Tandon VT,
Kirby BJ
"Ambient Pressure Effects on the Electrokinetic Potential of Zeonor-Water Interfaces,"
Journal of Colloid and Interface Science, 361:381-387, 2011.
doi
pdf
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Tandon VT,
Bhagavatula S,
Kirby BJ
"Transient Zeta Potential Measurements in Hydrophobic,
TOPAS Microfluidic Substrates,"
Electrophoresis 30(15) 2656-2667, 2009.
doi
pdf
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Tandon V,
Bhagavatula SK,
Nelson WC,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge",
Electrophoresis 29(5):1092-1101, 2008.
doi
pdf
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Tandon V,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure",
Electrophoresis 29(5):1102-1114, 2008.
doi
pdf
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Mela P, van den Berg A, Fintschenko Y,
Cummings EB, Simmons BA,
Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless)
dielectrophoresis particle trapping devices,"
Electrophoresis 26:1792-1799 (2005).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 1. Theory, experimental
techniques, and effects on separations,"
Electrophoresis, 25:187-202
(2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 2. Data for polymers,"
Electrophoresis, 25:203-213 (2004).
doi
pdf
text
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Reichmuth DS,
Kirby BJ
"Effects of
Ammonioalkyl sulfonate internal salts on electrokinetic
micropump performance and Reversed-Phase HPLC separations,"
Journal of Chromatography A, 1013:93-101
(2003).
doi
pdf
text
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Reichmuth DS, Chirica GS,
Kirby BJ
"Increasing the Performance of High-Pressure,
High-Efficiency Electrokinetic Micropumps Using Zwitterionic
Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003).
doi
pdf
text
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Kirby BJ,
Wheeler AR, Zare RN, Fruetel JA,
Shepodd TJ "Programmable Modification of Cell Adhesion
and Zeta Potential in Silica Microchips,"Lab On a Chip
3:5-10 (2003).
doi
pdf
text
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Presentations and Other Publications |
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7 Nov 2012
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Kirby BJ
"Electrokinetic and immunospecific characterization of cells for human health and energy applications",
SUNY-Buffalo Chemical and Biomolecular Engineering Seminar Series, Buffalo, NY.
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16-18 Jul 2012
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Kirby BJ
ICREA Symposium on Nanofluidics, Colloids, and Membranes, Barcelona, Spain.
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20-25 June 2010 |
Connelly JT,
Kondapalli S,
Skoupi M,
Parker JSL,
Kirby BJ,
Baeumner AJ
"Electrochemical biosensor with integrated preconcentration module
for the detection of enteric viruses,"
Gordon Research Conference on Bioanalytical Sensors, Colby-Sawyer College,
New London, NH.
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Tandon V, Bhagavatula SK, Kirby BJ
"Disruption of long-term electrokinetic transients in pressure driven flow via a short-term application of an electric field", MicroTAS 2009, Jeju, Korea.
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1-5 Nov 2009 |
Tandon V,
Bhagavatula SK,
Kirby BJ
"Disruption of long-term electrokinetic transients in
pressure driven flow via a short-term application of an electric field ",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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30 Jan 2009
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Kirby BJ
"Geometric micro- and mesopatterning for control of cell transport and microenvironemnt in microdevices and tissue-engineered scaffolds",
Carnegie-Mellon Mechanical Engineering Seminar Series, Pittsburgh, PA.
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12-16 Oct 2008
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Tandon V, Bhagavatula SK, Kirby BJ
"Transient Electrokinetic Phenomena in Hydrophobic Microfluidic Devices," 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), San Diego, CA.
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10 apr 2008
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Kirby BJ
"Electrokinetic Tool of Cellular Screening in Plastic Microdevices: Interfacial Characterization and Engineering Design",
Temple University Chemistry Department, Philadelphia, PA.
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4 Mar 2008
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Kirby BJ
"Micropatterning in injection-molded microdevices and engineered tissue scaffolds: the role of electrokinetic coupling",
University of Illinois Mechancal Science and Engineering Department, Urbana, IL
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4-9 Nov 2007 |
Tandon V,
Bhagavatula SK,
Nelson WC, Sharma AN,
Kirby BJ
"Electrokinetic and scanned probe microscopy characterization
of interfacial nanobubble phenomena in hydrophobic microfluidic
devices", AIChE 2007, Salt Lake City, UT, November 2007.
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7-12 Oct 2007. |
Hawkins BG,
Tandon V,
Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial
characterization and engineering design",
Meeting of the Electrochemical Society, Washington, DC.
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7-11 Oct 2007 |
Tandon V,
Bhagavatula SK,
Nelson WC, Sharma AN,
Kirby BJ
"Electrokinetic and scanned probe microscopy characterization
of interfacial nanobubble phenomena in hydrophobic microfluidic
devices", MicroTAS 2007, Paris, France, October 2007.
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15-20 Jul 2007 |
Tandon V,
Bhagavatula SK,
Nelson WC, Sharma AN,
Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH.
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10 May 2007
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Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems",
University of Toronto Analytical Chemistry Seminar Series, Toronto, Canada.
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24 Apr 2007
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Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems",
Lafayette Bioengineering and Biomedicine Symposium, Easton, PA.
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26 Feb 2007
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Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning",
Biological and Environmental Engineering Seminar Series, Cornell University, Ithaca, NY.
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25 Jan 2007
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Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning",
Textiles and Apparel Seminar Series, Cornell University, Ithaca, NY.
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6 Oct 2006
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Kirby BJ
"Fabrication for design and control of micro/nanofluidic systems",
University of Michigan Mechanical Engineering Seminar Series, Ann Arbor, MI.
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21 Jun 2006
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Kirby BJ
"Electrokinetics in fluid systems: Control of fields with multiscale geometric patterning",
2nd New York Complex Matter Workshop, Ithaca, NY.
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12 Jan 2006
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Kirby BJ
"Miniaturized devices for combinatorial chemistry and nanofluidic study",
Sandia National Laboratories, Livermore, CA.
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9 Dec 2005
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Kirby BJ
Kodak Research Laboratories, Rochester, NY.
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10 Nov 2005
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Kirby BJ
Mechanical Engineering and Applied Mechanics Department, University of Pennsylvania, Philadelphia, PA.
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27 Oct 2005
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Kirby BJ
Dept. of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark.
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18 Oct 2005
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Kirby BJ
Nanobiotechnology Center, Cornell University, Ithaca, NY.
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27 Sep 2005
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Kirby BJ
Cornell Fluid Dynamics Seminar, Ithaca, NY.
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25 July 2005
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Kirby BJ
Gordon Research Conference on the Physics and Chemistry of Microfluidics, Oxford, UK.
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10 Feb 2005
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Kirby BJ
APS March Annual Meeting, San Francisco, CA.
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10 Feb 2005
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Kirby BJ
Johns Hopkins Mechanical Engineering Seminar Series, Baltimore, MD.
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Oct 2001
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Kirby BJ,
Wheeler AR, Shepodd TJ, Fruetel JA,
Hasselbrink, Jr. EF, Zare RN "A Laser-Polymerized Thin
Film Silica Surface Modification for Suppression of Cell
Adhesion and Electroosmotic Flow in Microchannels,"
MicroTAS 2001, Kluwer Academic Publishers,
(2001).
pdf
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Oct 2001
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Wheeler AR, Morishima K,
Kirby BJ,
Leach A,
Zare RN "CATH.a Neuron Cell Analysis on a Chip With
Micellar Electrokinetic Chromatography," MicroTAS 2001,
Kluwer Academic Publishers, (2001).
pdf
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The evolution of electrokinetic potential observed at Zeonor-water
interfaces as a function of dissolved gas concentration.
(see ref at the journal website
here).
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Thin spun Nafion which we are using to
characterize
interfacial properties
of highly charged films.
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Streaming potential device for characterizing
interfacial properties
of Nafion films.
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News
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Monday, August 13, 2012 Scientific American reports on blood tests for cancer
Scientific American recently reported on blood tests for cancer, including our GEDI device--see the report here.
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Wednesday, August 01, 2012 Demystifying circulating tumor cells
See this article on circulating tumor cells in Genetic Engineering and Biotechnology News, featuring our GEDI microdevice among several CTC …
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Read more...
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Friday, June 29, 2012 Medical Device Daily reports on GEDI device
The GEDI device and related research was reported on in Medical Device Daily--see the writeup here.
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Thursday, June 28, 2012 The Force is with us: GEDI chip sorts prostate cancer cells
Our work was recently reported on in the Cornell Chronicle--see the article here or see the video below:
Embedded video from Cornell University
…
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Read more...
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Monday, June 18, 2012 Rouillard reports on mechanical regulation of fibroblasts
Kirbylab alumnus Andrew Rouillard and his advisor Jeff Holmes recently reported on fibroblast migration and collagen remodeling in healing myocardial …
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Read more...
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Thursday, June 14, 2012 Presentan en NY avances para personalizar tratamientos contra cáncer
Para leer este artículo, haz clic aquí o aquí.
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Friday, April 27, 2012 Cornell demonstrates functional characterization of circulating tumor cells
A team of Cornell-Ithaca and Weill-Cornell Medical College researchers reported today in PLoS ONE demonstration of functional characterization of …
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Read more...
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Saturday, March 31, 2012 Lannin wins NSF fellowship
Congratulations to Tim Lannin, who recently received an NSF fellowship. Good work Tim!
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Tuesday, February 21, 2012 Pratt wins CMM Young Investigator Award
We are excited to announce that Erica Pratt has won a Center for Microenvironment and Metastasis Young Investigator Award, which provided $25K direct …
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Read more...
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Tuesday, July 05, 2011 Polacheck reports on cancer cell migration in PNAS
Congrats to Kirbylab alumnus Bill Polacheck, whose first paper in Roger Kamm's lab just came out. Good work, Bill!
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