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Microparticle Processing
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Because microfluidic devices provide a well-defined geometry that can
straightforwardly be massively-parallelized, there exists a great potential
for processing particles in microsystems. Applications include:
- preprocessing complex samples to eliminate particles before injection into a
microfluidic device
- sorting particles so as to improve identification of pathogen spores
- controlled fabrication of nanoparticles
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Publications and Presentations on Microparticle Processing
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Hawkins BG,
Kirby BJ
"Electrothermal flow effects in insulating
(electrodeless) dielectrophoresis systems,"
submitted, 2010.
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Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices,"
Cambridge University Press, 2010.
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Cambridge University Press
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Gleghorn JP,
Pratt ED,
Denning D,
Liu H,
Bander NH,
Tagawa S,
Nanus DM,
Giannakakou PA,
Kirby BJ
"Capture of circulating tumor cells from whole blood of
prostate cancer patients using geometrically enhanced
differential immunocapture and a prostate-specific antibody",
Lab on a Chip, 10:27-29, 2010.
doi
pdf
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hawkins BG,
Huang C,
Stranic I,
Kondapalli SK,
Kirby BJ
"Particle screening in polymeric microfluidic devices using insulating
dielectrophoresis and frequency modulated electric fields", ",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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Kondapalli SK,
Connelly JT,
Baeumner AJ,
Kirby BJ
"On-chip electrophoretic concentration of liposomes
for antibody-based viral biosensors", ",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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Gleghorn JP,
Pratt ED,
Lofthus MS,
Levy BE,
Bander NH,
Nanus DM,
Giannakakou PA,
Kirby BJ
"High efficiency capture of circulating tumor cells
from patient blood using geometrically-enhanced differential immunocapture",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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Hawkins BG,
Gleghorn JP,
Kirby BJ
"Dielectrophoresis for cell and particle manipulations,"
in Methods in Bioengineering: Biomicrofabrication
and Biomicrofluidics, Ed. J.D. Zahn,
Artech Press, 2009.
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Hawkins BG,
Smith AE,
Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic
screening of Mycobacterium smegmatis in
coherently patterned, polymeric microchannels",
AIChE 2007, Salt Lake City, UT, November 2007.
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Hawkins BG,
Tandon V,
Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial
characterization and engineering design",
Meeting of the Electrochemical Society, Washington, DC, October 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic
screening of Mycobacterium smegmatis in
coherently patterned, polymeric microchannels",
MicroTAS 2007, Paris, France, October 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
"Towards cellular screening for Mycobacteria: Microchip
monitoring of electrical phenotype",
BMES 2007, Los Angeles, CA, September 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH, 2007.
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Hawkins BG,
Smith AE,
Syed YA,
Kirby BJ
"Continuous-flow particle separation by 3D insulative
dielectrophoresis using coherently shaped, DC-biased,
AC electric fields,"
Analytical Chemistry, 2007.
doi
pdf
text
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Hawkins BG,
Smith AE, Syed YA,
Kirby BJ
"Continuous-flow dielectrophoretic particle separation in polymeric
microchannels,"
3rd New York Complex Matter Workshop Syracuse, NY, Dec 2006.
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Hawkins BG,
Smith AE, Syed YA,
Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems,"
AIChE 2006 San Francisco, CA, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow particle sorting at low applied electric fields
using electrodeless dielectrophoresis in ridged polymeric devices,"
MicroTAS 2006 Tokyo, Japan, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow particle sorting at low applied electric fields
using electrodeless dielectrophoresis in ridged polymeric devices,"
ASME Congress 2006 Chicago, IL, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields,"
2nd New York Complex Matter Workshop Ithaca, NY, June 2006.
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Mela P, van den Berg A, Fintschenko Y,
Cummings EB, Simmons BA,
Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless)
dielectrophoresis particle trapping devices,"
Electrophoresis 26:1792-1799 (2005).
doi
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text
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Song S, Mela P, van den Berg A,
Kirby BJ
"Microfluidic architectures for integrated cell lysis,
lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004).
pdf
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Kirby BJ,
Wheeler AR, Zare RN, Fruetel JA,
Shepodd TJ "Programmable Modification of Cell Adhesion
and Zeta Potential in Silica Microchips,"Lab On a Chip
3:5-10 (2003).
doi
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text
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Kirby BJ,
Wheeler AR, Shepodd TJ, Fruetel JA,
Hasselbrink, Jr. EF, Zare RN "A Laser-Polymerized Thin
Film Silica Surface Modification for Suppression of Cell
Adhesion and Electroosmotic Flow in Microchannels,"
MicroTAS 2001, Kluwer Academic Publishers,
(2001).
pdf
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Wheeler AR, Morishima K,
Kirby BJ,
Leach A,
Zare RN "CATH.a Neuron Cell Analysis on a Chip With
Micellar Electrokinetic Chromatography," MicroTAS 2001,
Kluwer Academic Publishers, (2001).
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Dielectrophoretic manipulation of particles in ridged microstructures. Top view.
Black-white color table denotes local electric field magnitude.
Red and green visualize particle types.
Field of view in this movie is ~2000 microns.
Place mouse on image to animate. | |
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