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Lab-on-a-Chip and BioMEMS Devices
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Lab-on-a-chip devices (also known as
micro-total-analytical systems or microTAS) are
devices designed to miniaturize analytical or
bioanalytical techniques and integrate them
into a microfabricated format. Techniques such as chemical separations
(electrophoresis, chromatography, etc) or immunoassays
are incorporated into
microfabricated systems (typically glass, silicon or polymers) with a goal of increasing
performance, minimizing reagent requirements, and decreasing cost.
BioMEMS devices are similar,
typically focusing on MEMS (microelectromechanical systems)
with biological applications.
We use lab-on-a-chip devices to capture, sort, culture, or
study cells, study interfacial phenomena, and produce pharmaceuticals.
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Selected Publications and Presentations on Lab-on-a-Chip and BioMEMS devices
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Hawkins BG,
Kirby BJ
"Electrothermal flow effects in insulating
(electrodeless) dielectrophoresis systems,"
submitted, 2010.
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Pratt ED,
Huang C,
Hawkins BG,
Gleghorn JP,
Kirby BJ
"Rare cell capture in microfluidic devices, submitted, 2010.
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Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices,"
Cambridge University Press, 2010.
click here for html version|
Cambridge University Press
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Gleghorn JP,
Pratt ED,
Denning D,
Liu H,
Bander NH,
Tagawa S,
Nanus DM,
Giannakakou PA,
Kirby BJ
"Capture of circulating tumor cells from whole blood of
prostate cancer patients using geometrically enhanced
differential immunocapture and a prostate-specific antibody",
Lab on a Chip, 10:27-29, 2010.
doi
pdf
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Barbati AC,
Fang C,
Banker GA,
Kirby BJ
"Microfluidic culture devices for observation of axonal organelle transport", ",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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Kondapalli SK,
Connelly JT,
Baeumner AJ,
Kirby BJ
"On-chip electrophoretic concentration of liposomes
for antibody-based viral biosensors", ",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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Kirby BJ
"Nanofluidics" (book review),
Materials Today, 12(5) 51, 2009.
doi
pdf
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Tandon VT,
Bhagavatula S,
Kirby BJ
"Transient Zeta Potential Measurements in Hydrophobic,
TOPAS Microfluidic Substrates,"
Electrophoresis 30(15) 2656-2667, 2009.
doi
pdf
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Kondapalli S,
Kirby BJ
"Refolding of beta-galactosidase: Microfluidic device for reagent metering
and mixing and quantification of refolding yield,"
Microfluidics and Nanofluidics 7(2) 275-281, 2009.
doi
pdf
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Hawkins BG,
Gleghorn JP,
Kirby BJ
"Dielectrophoresis for cell and particle manipulations,"
in Methods in Bioengineering: Biomicrofabrication
and Biomicrofluidics, Ed. J.D. Zahn,
Artech Press, 2009.
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Kondapalli S,
Kirby BJ
"Refolding of beta-galactosidase: Microfluidic device for reagent metering
and mixing and quantification of refolding yield,"
AIChE 2008.
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George PA, Hui W, Rana F,
Hawkins BG,
Smith AE,
Kirby BJ
"Integrated microfluidic devices for terahertz spectroscopy of biomolecules",
Optics Express, 16(3) 1577-1582 (2008).
pdf
text
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Hawkins BG,
Smith AE,
Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic
screening of Mycobacterium smegmatis in
coherently patterned, polymeric microchannels",
MicroTAS 2007, Paris, France, October 2007.
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Tandon V,
Bhagavatula SK,
Nelson WC,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge",
Electrophoresis 29(5):1092-1101, 2008.
doi
pdf
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Tandon V,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure",
Electrophoresis 29(5):1102-1114, 2008.
doi
pdf
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Hawkins BG,
Smith AE,
Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH, 2007.
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Hawkins BG,
Smith AE,
Syed YA,
Kirby BJ
"Continuous-flow particle separation by 3D insulative
dielectrophoresis using coherently shaped, DC-biased,
AC electric fields,"
Analytical Chemistry, 2007.
doi
pdf
text
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Hawkins BG,
Smith AE, Syed YA,
Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems,"
AIChE 2006 San Francisco, CA, Nov 2006.
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Mela P, van den Berg A, Fintschenko Y,
Cummings EB, Simmons BA,
Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless)
dielectrophoresis particle trapping devices,"
Electrophoresis 26:1792-1799 (2005).
doi
pdf
text
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"Microchip HPLC of peptides and proteins,"
Analytical Chemistry 77:2997-3000 (2005).
doi
pdf
text
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Kirby BJ,
Reichmuth DS, Renzi RF, Shepodd TJ,
Wiedenman BJ "Microfluidic routing of aqueous and
organic flows at high pressure: Fabrication and
characterization of integrated polymer microvalve elements,"
Lab on a Chip 5:184-190 (2005).
doi
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text
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Reichmuth DS, Chirica GS,
Kirby BJ
"Analysis of peptides using an integrated
microchip HPLC-MS/MS system," in MicroTAS 2004, Kluwer Academic Publishers (2004).
pdf
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"On-chip
high-pressure picoliter injector for pressure-driven flow
through porous media," Analytical Chemistry
76:5063-5068 (2004).
doi
pdf
text
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Song S, Singh AK,
Kirby BJ
"Electrophoretic
Concentration of Proteins at Laser-Patterned Porous
Membranes," Analytical Chemistry 76:4589-4592 (2004).
doi
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Song S, Singh AK, Shepodd TJ,
Kirby BJ
"Microchip dialysis of proteins using in situ
photopatterned nanoporous polymer membranes", Analytical
Chemistry 76:2367-2373 (2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 1. Theory, experimental
techniques, and effects on separations,"
Electrophoresis, 25:187-202
(2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 2. Data for polymers,"
Electrophoresis, 25:203-213 (2004).
doi
pdf
text
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Fintschenko Y,
Kirby BJ,
Hasselbrink, Jr. EF,
Singh AK, Shepodd TJ "Monolithic Materials: Miniature
and Microchip Technologies," in Monolithic Materials:
Preparation, Properties, and Applications Elsevier,
Amsterdam (2003).
pdf
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Kirby BJ,
Wheeler AR, Zare RN, Fruetel JA,
Shepodd TJ "Programmable Modification of Cell Adhesion
and Zeta Potential in Silica Microchips,"Lab On a Chip
3:5-10 (2003).
doi
pdf
text
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Kirby BJ,
Shepodd TJ, Hasselbrink, Jr. EF
"Voltage-Addressable On/Off Microvalves for High-Pressure
Microchip Separations," Journal of Chromatography A
979:147-154 (2002).
doi
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Wheeler AR, Morishima K,
Kirby BJ,
Leach A,
Zare RN "CATH.a Neuron Cell Analysis on a Chip With
Micellar Electrokinetic Chromatography," MicroTAS 2001,
Kluwer Academic Publishers, (2001).
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