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Cellular Analysis
Lab-on-a-Chip devices provide an exciting opportunity to perform unique cellular analyses, due to the potential for:
  • processing of extraordinarily small volumes (comparable to cellular contents)
  • rapid automated analysis
  • analysis of single cells
Our interests related to cellular analysis focus mainly on dielectrophoretic manipulation of cells and microfluidic capture of circulating tumor cells.

Archival Publications

HTML version of Kirby: Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices," Cambridge University Press, 2010.
click here for html version| Cambridge University Press

HTML page for Wilkes: Fluid Mechanics for Chemical Engineers with Microfluidics and CFD

Wilkes JO , with Birmingham SG, Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD," Prentice-Hall, 2005.
click here to go to text webpage

Rhim AD, Thege FI, Santana SM, Lannin TB, Kochman ML, Ginsberg GG, Lieb JG, Chandrasekhar V, Drebin JA, Ahmad N, Yang Y-X, Kirby BJ, Stanger BZ
"Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions", submitted, 2012.

Zhu B, Smith JP, Yarmush M, Nahmias Y, Kirby BJ, Murthy S,
"Microfluidic Enrichment of Mouse Epidermal Stem Cells and Validation of Stem Cell Proliferation In Vitro, Tissue Engineering C, accepted, 2013.

Huang C, Santana SM, Liu H, Bander NH, Hawkins BG, Kirby BJ
"Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture", submitted, 2012.

PDF version of Barbati, Fang, Banker, Kirby:
Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic
device for cell seeding, coherent growth, and solute delivery

Barbati AC, Fang C, Banker GA, Kirby BJ,
"Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic device for cell seeding, coherent growth, and solute delivery", Biomedical Microdevices, published online 2012. doi pdf

PDF version of Kirby, Jodari, Loftus, Gakhar, Pratt, Chanel-Vos, Gleghorn, Santana, Liu, Smith, Navarro, Tagawa, Bander, Nanus, Giannakakou, Kirby:
Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

Kirby BJ, Jodari M, Loftus M, Gakhar G, Pratt ED, Chanel-Vos C, Gleghorn JP, Santana SM, Liu H, Smith JP, Navarro VN, Tagawa ST, Bander NH, Nanus DM, Giannakakou PA,
"Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device ", PLoS ONE, 7(4): e35976, 2012. doi pdf

Hawkins, Huang, Arasanipalai, Kirby: Automated dielectrophoretic chracterization of Mycobacterium smegmatis

Hawkins BG, Huang C, Arasanipalai S, Kirby BJ
"Automated dielectrophoretic chracterization of Mycobacterium smegmatis," Analytical Chemistry, 83 (9), pp 3507–3515, 2011. doi pdf

Gleghorn JP, Smith JP, Kirby BJ
"Spatial aliasing of particle displacements and collision rates in periodic asymmetric microfluidic obstacle arrays", submitted, 2011.

PDF version of Chandler, Berglund, Lee, Polacheck, Gleghorn, Fischbach: Stiffness of Photocrosslinked Alginate Gels Regulates
Adipose Progenitor Cell Behavior

Chandler EM, Berglund CM, Lee JS, Polacheck WJ, Gleghorn JP, Kirby BJ, Fischbach C
"Stiffness of Photocrosslinked Alginate Gels Regulates Adipose Progenitor Cell Behavior, Biotechnology and Bioengineering 108:7;1683-1692, 2011. doi pdf

PDF version of AUTHORS: TITLE

Rouillard AD, Berglund CM, Lee JY, Polacheck WJ, Tsui YT, Bonassar LJ, Kirby BJ
"Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability," Tissue Engineering C, Vol 17(2), 2011. doi pdf

PDF version of AUTHORS: TITLE

Pratt ED, Huang C, Hawkins BG, Gleghorn JP, Kirby BJ
"Rare cell capture in microfluidic devices, Chemical Engineering Science, Vol 66(7)1508-1522, 2011. doi PubMedCentral pdf

PDF version of Rouillard, Tsui, Polacheck, Lee, Bonassar, Kirby: 
Control of the Electromechanical Properties of
Alginate Hydrogels via Ionic and Covalent
Cross-Linking and Microparticle Doping

Rouillard AD, Tsui YT, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Control of the Electromechanical Properties of Alginate Hydrogels via Ionic and Covalent Crosslinking and Microparticle Doping," Biomacromolecules, 11 (8), pp 2184–2189, 2010. doi pdf

PDF version of Hawkins, Kirby: Electrothermal flow effects in insulating 
(electrodeless) dielectrophoresis systems

Hawkins BG, Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems," Electrophoresis, 31:3622-3633, 2010. doi pdf

PDF version of Gleghorn, Pratt, Denning, Liu, Bander, Tagawa, Nanus, Giannakakou, Kirby:
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody

Gleghorn JP, Pratt ED, Denning D, Liu H, Bander NH, Tagawa S, Nanus DM, Giannakakou PA, Kirby BJ
"Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture and a prostate-specific antibody", Lab on a Chip, 10:27-29, 2010. doi PubMedCentral pdf

PDF version of AUTHORS: TITLE

Hawkins BG, Gleghorn JP, Kirby BJ
"Dielectrophoresis for cell and particle manipulations," in Methods in Bioengineering: Biomicrofabrication and Biomicrofluidics, Ed. J.D. Zahn, Artech Press, 2009. pdf

PDF version of Brian Kirby Nanofluidics review

Kirby BJ
"Nanofluidics" (book review), Materials Today, 12(5) 51, 2009. doi pdf

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

Presentations and Other Publications
6-7 Jun 2013

Kirby BJ
Select Biosciences 2013 Nano and Microfluidics conference, CCH Congress Centre, Hamburg Germany.

17-21 Mar 2013

Kirby BJ
"Functional Characterization of Circulating Tumor Cells Captured With GEDI Microdevices", Pittcon 2013, Philadelphia, PA.

12-16 Nov 2012

Kirby BJ
World CTC Summit, Boston, MA.

7 Nov 2012

Kirby BJ
"Electrokinetic and immunospecific characterization of cells for human health and energy applications", SUNY-Buffalo Chemical and Biomolecular Engineering Seminar Series, Buffalo, NY.

24-27 Oct 2012

Pratt ED , Blattner M , Stepansky A , Liu H , Bander NH , Hicks J , Rubin MA , Kirby BJ
"Microfluidic Nuclei Extraction from Circulating Tumor Cells for Genetic Analyses", BMES 2012, Atlanta, Georgia.

24-27 Oct 2012

Huang C , Kirby BJ
"DEP-enhanced immunocapture of Circulating Tumor Cells in GEDI Microdevices", BMES 2012, Atlanta, Georgia.

24-27 Oct 2012

Santana SM , Fischbach C , Kirby BJ
"Immunocapture of Circulating Tumor Cells in Tissue-Engineered GEDI Microdevices", BMES 2012, Atlanta, Georgia.

24-27 Oct 2012

Kirby BJ
"Dielectric Spectrometry of Mycobacterium and GEDI Devices for Circulating Tumor Cells: Cell Capture, Characterization, and Manipulation in Geometrically Patterned Microstructures", BMES 2012, Atlanta, Georgia.

30 Sep-5 Oct 2012

Kirby BJ
"Dielectric and dielectrophoretic measurements and manipulations of cells for human health and energy applications", SciX 2012, Kansas City, MO.

19-21 Sep 2012

Kirby BJ
CHI ADAPT 2012, Washington, DC.

17 Aug 2012

Huang C , Santana SM , Hawkins BG , Liu H , Bander NH , Kirby BJ
"Dielectrophoresis-Enhanced Immunocapture of Prostate Cancer Cells", cornell BMES Retreat, Ithaca, NY.

10-13 May 2012

Kirby BJ
"Geometric patterning: controlling small-scale flows with repeated microstructures", German--American Frontiers of Science Symposium, Potsdam, Germany. | video

31 Mar-4 Apr 2012

Galletti G, , Kirby BJ , Vahdat L , Giannakakou PA
Development of a novel microfluidic device for the capture and molecular characterization of circulating tumor cells from metastatic breast cancer patients 103nd annual AACR meeting 2012, Chicago, IL.

31 Mar-4 Apr 2012

Sung M , Loftus M , Jodari-Karimi M , Pratt ED , Gakhar G , Rubin M , Bander N , Novaro , Tagawa ST , Kirby BJ , Nanus DM , Giannakakou PA
Molecular and functional analysis of circulating prostate tumor cells with anti-PSMA immunocapture 103nd annual AACR meeting 2012, Chicago, IL.

28 Mar 2012

Bono MS , Rhoads K , Ahner BA , Kirby BJ
Dielectric measurement of algal lipid content, Division of Analytical Chemistry oral session on "Challenges in Algal Biofuels: Biochemistry, Lipid Extraction and Analysis" at the 243rd ACS National Meeting, San Diego, California.

2-3 Feb 2012

Kirby BJ
Select Biosciences Meeting on Circulating Tumor Cells, San Diego, CA.

12-15 Oct 2011

Kirby BJ, Pratt ED, Santana SM, Smith JP, Gleghorn JP, Liu H, Bander NH, Jodari M, Loftus M, Nanus DM, Giannakakou PA,
"Functional Characterization of drug-target engagement on high-purity CTCs correlate with patient progression", BMES 2011, Hartford, CT.

6-9 Oct 2011

Huang C , Hawkins BG , Arasanipalai S , Kirby BJ
Dielectrophoretic characterization of Mycobacteria and Prostate Cancer Cells, BMES 2011 Annual Meeting, Hartford, CT.

2-6 Oct 2011

Kirby BJ, Pratt ED, Santana SM, Smith JP, Gleghorn JP, Jodari M, Gakhar G, Loftus M, Liu H, Bander NH, Nanus DM, Giannakakou PA,
"Functional Characterization of drug-target engagement on high-purity CTCs correlate with patient progression", MicroTAS 2011, Seattle, WA.

2-6 Oct 2011

Pratt ED, Santana SM, Gleghorn JP, Liu H, Bander NH, Nanus DM, Giannakakou PA, Kirby BJ
"Circulating tumor cell release by use of novel immunocapture chemistry in GEDI microdevices", MicroTAS 2011, Hartford, CT.

1 Oct 2011

Kirby BJ
Microfluidic capture of circulating tumor cells for assay of chemotherapeutic efficacy: system design and translation to the clinical setting Cornell Translational Cancer Research Symposium, Ithaca, NY

15 sept 2011

Arasanipalai S , Hawkins BG , Huang C , Kirby BJ
Dielectrophoretic separation of Mycobacteria to aid in Tuberculosis research, CNF 2011 Annual Meeting, Ithaca, NY.

10 Jun 2011

Arasanipalai S , Huang C , Hawkins BG , Kirby BJ
Dielectrophoretic separation of Mycobacteria to aid in tuberculosis research, 11th New York Complex Matter Workshop, Syracuse, NY.

10 Jun 2011

Bono MS , Rhoads K , Ahner BA , Kirby BJ
Dielectric measurement of algal lipid content for biodiesel production, 11th New York Complex Matter Workshop, Syracuse, NY.

19-20 Apr 2011

Kirby BJ
NSF National Nanotechnology Infrastructure Network Computation Symposium, Ann Arbor, MI.

2-6 Apr 2011

Loftus M , Jodari-Karimi M , Pratt ED , Gakhar G , Rubin M , Bander N , Novaro , Tagawa ST , Kirby BJ , Nanus DM , Giannakakou PA
Molecular and functional analysis of circulating tumor cells in castrate resistant prostate cancer using a geometrically enhanced microfluidic device based on PSMA immunocapture, 102nd annual AACR meeting 2011, Orlando, FL.

30 Mar 2011

Bono MS , Kirby BJ
Microfluidic dielectric spectroscopy of particle and cell solutions, Division of Analytical Chemistry poster session at the 241st ACS National Meeting, Anaheim, California.

23-25 Feb 2011

Kirby BJ
CHI Meeting on Circulating Tumor Cells (CTCs) for Cancer Detection, Diagnosis, Prognosis and Treatment, San Francisco, CA.

17-19 Feb 2011

Jodari M , Loftus M , Gleghorn JP , Gakhar G , Pratt ED , Tagawa ST , Bander NH , Giannakakou PA , Kirby BJ , Nanus DM
"Capture and analysis of prostate cancer circulating tumor cells (CTCS) by use of geometrically enhanced differential immunocapture (GEDI)", 2011 Genitourinary Cancers Symposium, Orlando, FL.

7-11 Feb 2011

Kirby BJ
Lorentz workshop on circulating tumor cells, Leiden, The Netherlands.

12-18 Nov 2010

Smith JP , Gleghorn JP , Kirby BJ
"Particle collision dynamics of microparticles in microfluidic obstacle arrays", ASME 2010 International Mechanical Engineering Congress and Exposition, Vancouver, BC.

7-12 Nov 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", AIChE 2010, Salt Lake City, UT.

7-12 Nov 2010

Gleghorn JP , Smith JP , Kirby BJ
"Particle collision dynamics of microparticles in microfluidic obstacle arrays", AIChE 2010, Salt Lake City, UT.

6-9 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", BMES 2010, Austin, TX.

6-9 Oct 2010

Huang C , Hawkins BG , Arisanipalai S , Kirby BJ
"Automated dielectrophoretic characterization for microfluidic cell separation devices", BMES 2010, Austin, TX.

3-7 Oct 2010

Barbati AC , Fang C , Banker GA , Kirby BJ
"Experimentation and modeling of a microfluidic device demonstrating geometric coercion for the directed growth and observation of rat hippocampal neurons", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Huang C , Hawkins BG , Arisanipalai S , Kirby BJ
"Automated dielectrophoretic characterization for microfluidic cell separation devices", MicroTAS 2010, Groningen, The Netherlands.

22 Sep 2010

Kirby BJ
"Microfluidic capture and analysis of CTCs from peripheral blood of prostate cancer patients", Georgia Tech Chemical and Biomolecular Engineering Seminar, Atlanta, GA.

15 July 2010

Kirby BJ
"Microfluidic devices for capture and analysis of prostate cancer CTCs from peripheral blood samples", Memorial Sloan-Kettering Cancer Center, New York, NY.

20-25 June 2010

Pratt ED , Gleghorn JP , Santana SM , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", Gordon Research Conference on Bioanalytical Sensors, Colby-Sawyer College, New London, NH.

20-25 June 2010

Kirby BJ
"Microfluidic devices for capture and analysis of prostate cancer CTCs from peripheral blood samples", Gordon Research Conference on Bioanalytical Sensors, Colby-Sawyer College, New London, NH.

18 June 2010

Smith JP, Gleghorn JP, Kirby BJ
"Particle Collision Dynamics in Geometrically Enhanced Differential Immunocapture (GEDI) Microdevices", 10th New York Complex Matter Workshop, Ithaca, NY.

18 June 2010

Santana SM, Gleghorn JP, Kirby BJ
"Immunocapture and Release of Viable Circulating Tumor Cells in Microdevices", 10th New York Complex Matter Workshop, Ithaca, NY.

18 June 2010

Huang C, Hawkins BG, Kirby BJ
"Automated Dielectrophoretic Characterization for Microfluidic Cell Separation", 10th New York Complex Matter Workshop, Ithaca, NY.

17-21 April 2010

Loftus MS , Gleghorn JP , Pratt ED , Bander NH , Nanus DM , Kirby BJ
Giannakakou P
"Analysis of circulating tumor cells from castrate resistant prostate cancer patients captured via a microfluidic device using an anti-PSMA antibody", American Association of Cancer Researchers 2010 Annual Meeting, Washington, DC.

6-9 Mar 2010

Rouillard AD, Berglund CM, Lee JY, Polacheck WJ, Tsui YT, Bonassar LJ, Kirby BJ
"Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability," Orthopedic Research Society Meeting, New Orleans, LA, March 2010.

1-5 Nov 2009 Barbati AC , Fang C, Banker GA, Kirby BJ
"Microfluidic Device and Culture Platform for the Observation and Control of Axonal Growth and Axonal Organelle Transport of Rat Hippocampal Neurons", MicroTAS 2009, Jeju, Korea.
1-5 Nov 2009

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"On-chip electrophoretic concentration of liposomes for antibody-based viral biosensors", MicroTAS 2009, Jeju, Korea.

1-5 Nov 2009 Gleghorn JP, Pratt ED, Loftus MS, Levy BE, Bander NH, Nanus DM, Giannakakou PA, Kirby BJ
"High efficiency capture of circulating tumor cells from patient blood using geometrically-enhanced differential immunocapture", MicroTAS 2009, Jeju, Korea.
27 Jun-3 Jul 2009

Hawkins BG, Kirby BJ
Gordon Research Conference on Microfluidics, Lucca, Italy.

27 Jun-3 Jul 2009

Barbati AC, Kirby BJ
Gordon Research Conference on Microfluidics, Lucca, Italy.

5 Mar 2009

Berglund CM, Lee JY, Yang W, Lee JS, Chandler EM, Fischbach CF, Kirby BJ
"Synthesis and Characterization of Photocrosslinked Alginate Hydrogels", Bioengineering Expo, Ithaca, NY.

5 Mar 2009

Lee JY, Berglund CM, Yang W, Gleghorn JP, Bonassar LJ, Kirby BJ
"Biological Characterization of Chondrocytes Seeded in Photocrosslinked Alginate Tissue Scaffolds", Bioengineering Expo, Ithaca, NY.

30 Jan 2009

Kirby BJ
"Geometric micro- and mesopatterning for control of cell transport and microenvironemnt in microdevices and tissue-engineered scaffolds", Carnegie-Mellon Mechanical Engineering Seminar Series, Pittsburgh, PA.

27 Oct 2008

Kirby BJ
"Geometric patterning to control cell growth, capture, and transport", NBTC Annual Symposium, Ithaca, NY.

12-16 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic range particle separation via insulating dielectrophoresis", 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), San Diego, CA.

2-4 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic Range Dielelectrophoresis Devices for Cell Screening," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

9-13 July 2008 Hawkins BG, Gleghorn JP, Kondapalli S, Kirby BJ
"Sorting, capture, and concentration of cells in microdevices: geometric design", Joint meeting of the International Society of Biorheology (ISB) and the International Society for Clinical Hemorheology (ISCH), University Park, PA.
10 apr 2008

Kirby BJ
"Electrokinetic Tool of Cellular Screening in Plastic Microdevices: Interfacial Characterization and Engineering Design", Temple University Chemistry Department, Philadelphia, PA.

21 Mar 2008

Kirby BJ
"Cell processing in microdevices: sorting, capturing, and concentration techniques", University of Rochester Biomedical Engineering Department, Rochester, NY.

4 Mar 2008

Kirby BJ
"Micropatterning in injection-molded microdevices and engineered tissue scaffolds: the role of electrokinetic coupling", University of Illinois Mechancal Science and Engineering Department, Urbana, IL

4-9 Nov 2007

Hawkins BG, Smith AE, Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic screening of Mycobacterium smegmatis in coherently patterned, polymeric microchannels", AIChE 2007, Salt Lake City, UT, November 2007.

7-12 Oct 2007.

Hawkins BG, Tandon V, Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial characterization and engineering design", Meeting of the Electrochemical Society, Washington, DC.

7-11 Oct 2007

Hawkins BG, Smith AE, Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic screening of Mycobacterium smegmatis in coherently patterned, polymeric microchannels", MicroTAS 2007, Paris, France, October 2007.

7-11 Oct 2007

Rouillard AD, Tsui Y, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Micropatterned hydrogel tissue scaffolds with controlled electrokinetic properties for investigation of chondrocyte mechanotransduction", MicroTAS 2007, Paris, France, October 2007.

1 Oct 2007
PDF version of Chandler, Berglund, Lee, Polacheck, Gleghorn, Fischbach: Stiffness of Photocrosslinked Alginate Gels Regulates
Adipose Progenitor Cell Behavior

Chandler EM, Cossell CM, Polacheck WJ, Lee JY, Kirby BJ, Fischbach C
"Effect of Substrate Stiffness on Heterotypic Cellular Interactions in Breast Cancer, Nanobiotechnology Symposium, Cornell University, Ithaca, NY. doi pdf

1 Oct 2007 Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype," Nanobiotechnology Symposium, Cornell University, Ithaca, NY.
26-29 Sep 2007

Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype,"  BMES 2007, Los Angeles, CA.

26-29 Sep 2007

Rouillard AD, Tsui Y, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Control of the electromechanical proterties of alginate tissue scaffolds via ionic and covalent crosslinking and microparticle doping", BMES 2007, Los Angeles, CA

15-20 Jul 2007

Hawkins BG, Smith AE, Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH.

10 May 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", University of Toronto Analytical Chemistry Seminar Series, Toronto, Canada.

24 Apr 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", Lafayette Bioengineering and Biomedicine Symposium, Easton, PA.

26 Feb 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Biological and Environmental Engineering Seminar Series, Cornell University, Ithaca, NY.

25 Jan 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Textiles and Apparel Seminar Series, Cornell University, Ithaca, NY.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," ASME Congress 2006 Chicago, IL.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan.

6 Oct 2006

Kirby BJ
"Fabrication for design and control of micro/nanofluidic systems", University of Michigan Mechanical Engineering Seminar Series, Ann Arbor, MI.

20 Sep 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," CNF annual meeting, Ithaca, NY

Nov 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems," AIChE 2006 San Francisco, CA.

Oct 2006

Rouillard AD, Bonassar LJ, Kirby BJ
"Control of electrokinetic properties of hydrogels for studies of mechanotransduction in chondrocytes," BMES Annual Meeting Chicago, IL.

21 Jun 2006

Kirby BJ
"Electrokinetics in fluid systems: Control of fields with multiscale geometric patterning", 2nd New York Complex Matter Workshop, Ithaca, NY.

Jun 2006

Rouillard AD, Bonassar LJ, Kirby BJ
"Studying cell mechanotransduction in chondrocytes via manipulation of electrokinetics in alginate hydrogels," 2nd New York Complex Matter Workshop Ithaca, NY.

Dec 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow dielectrophoretic particle separation in polymeric microchannels," 3rd New York Complex Matter Workshop Syracuse, NY.

12 Jan 2006

Kirby BJ
"Miniaturized devices for combinatorial chemistry and nanofluidic study", Sandia National Laboratories, Livermore, CA.

9 Dec 2005

Kirby BJ
Kodak Research Laboratories, Rochester, NY.

10 Nov 2005

Kirby BJ
Mechanical Engineering and Applied Mechanics Department, University of Pennsylvania, Philadelphia, PA.

27 Oct 2005

Kirby BJ
Dept. of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark.

18 Oct 2005

Kirby BJ
Nanobiotechnology Center, Cornell University, Ithaca, NY.

27 Sep 2005

Kirby BJ
Cornell Fluid Dynamics Seminar, Ithaca, NY.

25 July 2005

Kirby BJ
Gordon Research Conference on the Physics and Chemistry of Microfluidics, Oxford, UK.

Jun 2005

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields," 2nd New York Complex Matter Workshop Ithaca, NY.

10 Feb 2005

Kirby BJ
APS March Annual Meeting, San Francisco, CA.

10 Feb 2005

Kirby BJ
Johns Hopkins Mechanical Engineering Seminar Series, Baltimore, MD.

Oct 2004
PDF version of Song, Mela, van den Berg, Kirby: Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus

Song S, Mela P, van den Berg A, Kirby BJ
"Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

Oct 2001
PDF version of Kirby, Wheeler, Shepodd, Fruetel, Hasselbrink, Zare: A laser-polymerized thin film silica surface modification for suppression of cell adhesion and electroosmotic flow in microchannels

Kirby BJ, Wheeler AR, Shepodd TJ, Fruetel JA, Hasselbrink, Jr. EF, Zare RN
"A Laser-Polymerized Thin Film Silica Surface Modification for Suppression of Cell Adhesion and Electroosmotic Flow in Microchannels," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Oct 2001
PDF version of Wheeler, Morishima, Kirby, Leach, Zare: CATH.a neuron cell analysis on a chip with micellar electrokinetic chromatography

Wheeler AR, Morishima K, Kirby BJ, Leach A, Zare RN
"CATH.a Neuron Cell Analysis on a Chip With Micellar Electrokinetic Chromatography," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Growth curves for Chlorella vulgaris (blue) and Chlamydomonas reinhardtii (green), measured via chlorophyll autofluorescence.
A circulating tumor cell captured by a GEDI device (refs here and here) from peripheral blood of a castrate-resistant prostate cancer patient shows differential response to chemotherapeutics that echoes clinical response. Top: immunofluorescent stain of tubulin of a circulating tumor cell incubated with 100 nM docetaxel (Taxotere) shows diffuse tubulin and no evidence of bundling. The absence of taxane response is indicative of a lack of drug-target engagement and is consistent with this patient's failure to response to Taxotere therapy. Bottom: immunofluorescent stain of tubulin of a cirulating tumor cell from the same patient incubated with 100 nM paclitaxel (Taxol) shows pronounced tubulin bundling, indicative of drug-target engagement and consistent with this patient's positive clinical response to Taxol.
Top: Collision rates of cells in obstacle arrays as a function of row offsets. Straight arrays (yellow) lead to low cancer cell capture efficiency (bottom left) whereas GEDI arrays (refs here and here) lead to high cancer cell capture efficiency (bottom right).
News

Monday, August 13, 2012
Scientific American reports on blood tests for cancer

Scientific American recently reported on blood tests for cancer, including our GEDI device--see the report here.
 

Wednesday, August 01, 2012
Demystifying circulating tumor cells

See this article on circulating tumor cells in Genetic Engineering and Biotechnology News, featuring our GEDI microdevice among several CTC …
Read more...
 

Friday, June 29, 2012
Medical Device Daily reports on GEDI device

The GEDI device and related research was reported on in Medical Device Daily--see the writeup here.
 

Thursday, June 28, 2012
The Force is with us: GEDI chip sorts prostate cancer cells

Our work was recently reported on in the Cornell Chronicle--see the article here or see the video below: Embedded video from Cornell University …
Read more...
 

Monday, June 18, 2012
Rouillard reports on mechanical regulation of fibroblasts

Kirbylab alumnus Andrew Rouillard and his advisor Jeff Holmes recently reported on fibroblast migration and collagen remodeling in healing myocardial …
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Thursday, June 14, 2012
Presentan en NY avances para personalizar tratamientos contra cáncer

Para leer este artículo, haz clic aquí o aquí.
 

Friday, April 27, 2012
Cornell demonstrates functional characterization of circulating tumor cells

A team of Cornell-Ithaca and Weill-Cornell Medical College researchers reported today in PLoS ONE demonstration of functional characterization of …
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Saturday, March 31, 2012
Lannin wins NSF fellowship

Congratulations to Tim Lannin, who recently received an NSF fellowship.  Good work Tim!
 

Tuesday, February 21, 2012
Pratt wins CMM Young Investigator Award

We are excited to announce that Erica Pratt has won a Center for Microenvironment and Metastasis Young Investigator Award, which provided $25K direct …
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Tuesday, July 05, 2011
Polacheck reports on cancer cell migration in PNAS


Congrats to Kirbylab alumnus Bill Polacheck, whose first paper in Roger Kamm's lab just came out.  Good work, Bill!
 

Thursday, June 23, 2011
Barbati to chair international Gordon Research Seminar on Microfluidics

During 25-26 June 2011, Alex Barbati will serve as the Chair of the international Gordon Research Seminar on the Physics and Chemistry of …
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Wednesday, June 08, 2011
Announcing the 2011 Microfluidics GRC

We are pleased to announce the 2011 Microfluidics GRC!  Please click the link to see the workshop program and other details.
Click here for workshop program
 

Thursday, May 12, 2011
Kirbylab receives grant for genetic analysis of circulating tumor cells

Kirbylab received NCI support today for several genetic analyses of circulating tumor cells.  The work, in collaboration with Weill Cornell …
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Wednesday, April 27, 2011
Multi-institutional team chosen to probe cytoskeletal architecture in CTCs

The NIH-NCI Physical Sciences in Oncology Program has selected several multi-institutional teams for funding to probe heterogeneity in cancer systems.…
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Monday, April 04, 2011
Hawkins reports on automated characterization of Mycobacterium

Congratulations to Ben, Charlie, and Nitya, whose paper (click here) was published in Analytical Chemistry today.  Their work involves …
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Tuesday, March 15, 2011
Pratt and Huang report on rare cell capture in microfluidic devices

Erica and Charlie's paper on rare cell capture in microfluidic devices has recently appeared in Chemical Engineering Science.
 

Thursday, February 24, 2011
Link between substrate stiffness and adipose differentiation reported

Work from collaborative efforts between Brian Kirby's and Claudia Fischbach's lab was reported in Biotechnology and Bioengineering today (click here …
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Tuesday, February 15, 2011
Rouillard reports on high-viability photocrosslinked alginate

Andrew Rouillard's paper on high-viability photocrosslinking of alginate has recently appeared in Tissue Engineering C.
 

Monday, November 29, 2010
Kirby to present at CTC Meeting in San Francisco

Professor Kirby will present our work on circulating tumor cell capture at the CHI meeting on circulating tumor cells (CTCs) for Cancer Detection, …
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Sunday, November 21, 2010
Kirby to present at Lorentz CTC workshop

Professor Kirby will give a keynote lecture on our work on circulating tumor cell capture at the Lorentz workshop on circulating tumor cells in …
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