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Brian J. Kirby Publications

HTML version of Kirby: Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices," Cambridge University Press, 2010.
click here for html version| Cambridge University Press

HTML page for Wilkes: Fluid Mechanics for Chemical Engineers with Microfluidics and CFD

Wilkes JO , with Birmingham SG, Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD," Prentice-Hall, 2005.
click here to go to text webpage

Rhim AD, Thege FI, Santana SM, Lannin TB, Kochman ML, Ginsberg GG, Lieb JG, Chandrasekhar V, Drebin JA, Ahmad N, Yang Y-X, Kirby BJ, Stanger BZ
"Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions", submitted, 2012.

Zhu B, Smith JP, Yarmush M, Nahmias Y, Kirby BJ, Murthy S,
"Microfluidic Enrichment of Mouse Epidermal Stem Cells and Validation of Stem Cell Proliferation In Vitro, Tissue Engineering C, accepted, 2013.

Huang C, Santana SM, Liu H, Bander NH, Hawkins BG, Kirby BJ
"Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture", submitted, 2012.

PDF version of Smith, Barbati, Santana, Gleghorn, Kirby:
Microfluidic transport in microdevices for rare cell capture

Smith JP, Barbati AC, Santana SM, Gleghorn JP, Kirby BJ,
"Microfluidic Transport in Microdevices for Rare Cell Capture", Electrophoresis, 33:3133-3142, 2012. doi pdf

PDF version of Diamond, Lee, Akhtar, Kirby, Giannakakou, Nanus:
Isolation and characterization of circulating tumor cells in prostate cancer

Diamond E, Lee GY, Akhtar NH, Kirby BJ, Giannakakou PA, Tagawa ST, Nanus DM,
"Isolation and characterization of circulating tumor cells in prostate cancer", Frontiers in Cancer Molecular Targets and Therapeutics, 2:131, 2012. doi pdf

PDF version of Barbati, Fang, Banker, Kirby:
Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic
device for cell seeding, coherent growth, and solute delivery

Barbati AC, Fang C, Banker GA, Kirby BJ,
"Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic device for cell seeding, coherent growth, and solute delivery", Biomedical Microdevices, published online 2012. doi pdf

PDF version of Barbati, Kirby:
Soft Diffuse Interfaces in Electrokinetics - Theory and experiment for transport in charged diffuse layers

Barbati AC, Kirby BJ,
"Soft Diffuse Interfaces in Electrokinetics - Theory and experiment for transport in charged diffuse layers", Soft Matter, 8:10598-10613, 2012. doi pdf

Akhtar N, Osborne J, Navarro V, Kirby BJ, Nanus DM, Tagawa ST
"Decrease in circulating tumor cells in response to antiandrogen withdrawal in a patient with metastatic prostate cancer, submitted, 2012.

PDF version of Kirby, Jodari, Loftus, Gakhar, Pratt, Chanel-Vos, Gleghorn, Santana, Liu, Smith, Navarro, Tagawa, Bander, Nanus, Giannakakou, Kirby:
Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

Kirby BJ, Jodari M, Loftus M, Gakhar G, Pratt ED, Chanel-Vos C, Gleghorn JP, Santana SM, Liu H, Smith JP, Navarro VN, Tagawa ST, Bander NH, Nanus DM, Giannakakou PA,
"Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device ", PLoS ONE, 7(4): e35976, 2012. doi pdf

PDF version of authors title

Santana SM, Liu H, Bander NH, Gleghorn JP, Kirby BJ,
"Immunocapture of Prostate Cancer Cells with Anti-PSMA Antibodies in Microdevices", Biomedical Microdevices, Volume 14, Number 2, Pages 401-407, 2012. doi pdf

PDF version of Connelly Kondapalli Parker Kirby Baeumner: Micro total analysis system for virus detection:microfluidic pre-concentration coupled to liposome-based detection

Connelly JT, Kondapalli S, Skoupi M, Parker JSL, Kirby BJ, Baeumner AJ
"Micro total analysis system for virus detection:microfluidic pre-concentration coupled to liposome-based detection," Analytical and Bioanalytical Chemistry, Volume 402, Number 1, 315-323, 2012. doi pdf

PDF version of Kondapalli Connelly Baeumner Kirby: Integrated microfluidic preconcentrator and immunobiosensor

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"Integrated microfluidic preconcentrator and immunobiosensor," Microfluidics and Nanofluidics, Volume 11, Number 5, 537-544, 2011. doi pdf

PDF version of Tandon Kirby: Ambient Pressure Effects on the Electrokinetic Potential of Zeonor-Water Interfaces

Tandon VT, Kirby BJ
"Ambient Pressure Effects on the Electrokinetic Potential of Zeonor-Water Interfaces," Journal of Colloid and Interface Science, 361:381-387, 2011. doi pdf

Hawkins, Huang, Arasanipalai, Kirby: Automated dielectrophoretic chracterization of Mycobacterium smegmatis

Hawkins BG, Huang C, Arasanipalai S, Kirby BJ
"Automated dielectrophoretic chracterization of Mycobacterium smegmatis," Analytical Chemistry, 83 (9), pp 3507–3515, 2011. doi pdf

Gleghorn JP, Smith JP, Kirby BJ
"Spatial aliasing of particle displacements and collision rates in periodic asymmetric microfluidic obstacle arrays", submitted, 2011.

PDF version of Chandler, Berglund, Lee, Polacheck, Gleghorn, Fischbach: Stiffness of Photocrosslinked Alginate Gels Regulates
Adipose Progenitor Cell Behavior

Chandler EM, Berglund CM, Lee JS, Polacheck WJ, Gleghorn JP, Kirby BJ, Fischbach C
"Stiffness of Photocrosslinked Alginate Gels Regulates Adipose Progenitor Cell Behavior, Biotechnology and Bioengineering 108:7;1683-1692, 2011. doi pdf

PDF version of AUTHORS: TITLE

Rouillard AD, Berglund CM, Lee JY, Polacheck WJ, Tsui YT, Bonassar LJ, Kirby BJ
"Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability," Tissue Engineering C, Vol 17(2), 2011. doi pdf

PDF version of AUTHORS: TITLE

Pratt ED, Huang C, Hawkins BG, Gleghorn JP, Kirby BJ
"Rare cell capture in microfluidic devices, Chemical Engineering Science, Vol 66(7)1508-1522, 2011. doi PubMedCentral pdf

PDF version of Rouillard, Tsui, Polacheck, Lee, Bonassar, Kirby: 
Control of the Electromechanical Properties of
Alginate Hydrogels via Ionic and Covalent
Cross-Linking and Microparticle Doping

Rouillard AD, Tsui YT, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Control of the Electromechanical Properties of Alginate Hydrogels via Ionic and Covalent Crosslinking and Microparticle Doping," Biomacromolecules, 11 (8), pp 2184–2189, 2010. doi pdf

PDF version of Hawkins, Kirby: Electrothermal flow effects in insulating 
(electrodeless) dielectrophoresis systems

Hawkins BG, Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems," Electrophoresis, 31:3622-3633, 2010. doi pdf

PDF version of Tandon Kirby: Transient zeta potential measuremnts in hydrophobic topas microfluidics substrates

Tandon VT, Bhagavatula S, Kirby BJ
"Transient Zeta Potential Measurements in Hydrophobic, TOPAS Microfluidic Substrates," Electrophoresis 30(15) 2656-2667, 2009. doi pdf

PDF version of Gleghorn, Pratt, Denning, Liu, Bander, Tagawa, Nanus, Giannakakou, Kirby:
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody

Gleghorn JP, Pratt ED, Denning D, Liu H, Bander NH, Tagawa S, Nanus DM, Giannakakou PA, Kirby BJ
"Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture and a prostate-specific antibody", Lab on a Chip, 10:27-29, 2010. doi PubMedCentral pdf

PDF version of AUTHORS: TITLE

Hawkins BG, Gleghorn JP, Kirby BJ
"Dielectrophoresis for cell and particle manipulations," in Methods in Bioengineering: Biomicrofabrication and Biomicrofluidics, Ed. J.D. Zahn, Artech Press, 2009. pdf

PDF version of Brian Kirby Nanofluidics review

Kirby BJ
"Nanofluidics" (book review), Materials Today, 12(5) 51, 2009. doi pdf

PDF version of Refolding of beta-galactosidase: microfluidic device for reagent metering and mixing and quantification of refolding yield 
Sowmya Kondapalli and Brian J. Kirby

Kondapalli S, Kirby BJ
"Refolding of beta-galactosidase: Microfluidic device for reagent metering and mixing and quantification of refolding yield," Microfluidics and Nanofluidics 7(2) 275-281, 2009. doi pdf

PDF version of Tandon V Bhagavatula SK Nelson WC Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge

Tandon V, Bhagavatula SK, Nelson WC, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge", Electrophoresis 29(5):1092-1101, 2008. doi pdf

PDF version of Tandon V Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices 
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure

Tandon V, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 2. Slip and interfacial water structure", Electrophoresis 29(5):1102-1114, 2008. doi pdf

PDF version of George, Rana, Hawkins, Kirby: 
Microfluidic devices for terahertz spectroscopy of biomolecules

George PA, Hui W, Rana F, Hawkins BG, Smith AE, Kirby BJ
"Integrated microfluidic devices for terahertz spectroscopy of biomolecules", Optics Express, 16(3) 1577-1582 (2008). doi pdf text

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

PDF version of Ghosh, Bhagwat, Renshaw, Goh, Gaeta, Kirby: Low-light-level optical interactions with rubidium vapor in a photonic band-gap fiber

Ghosh S, Bhagwat AR, Renshaw CK, Goh S, Gaeta AL, Kirby BJ
"Low-light-level optical interactions with rubidium vapor in a photonic band-gap fiber," Physical Review Letters 97:023603 (2006). doi pdf arxiv

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

PDF version of Song, Singh, Kirby: Electrophoretic concentration of proteins at laser-patterned porous membranes

Song S, Singh AK, Kirby BJ
"Electrophoretic Concentration of Proteins at Laser-Patterned Porous Membranes," Analytical Chemistry 76:4589-4592 (2004). doi pdf text

PDF version of Song, Singh, Shepodd, Kirby: Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes", Analytical Chemistry 76:2367-2373 (2004). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: On-chip high-pressure picoliter injector for pressure-driven flow through porous media

Reichmuth DS, Shepodd TJ, Kirby BJ
"On-chip high-pressure picoliter injector for pressure-driven flow through porous media," Analytical Chemistry 76:5063-5068 (2004). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 1. Theory, experimental techniques, and effects on separations

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 1. Theory, experimental techniques, and effects on separations," Electrophoresis, 25:187-202 (2004). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 2. Data for polymers

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 2. Data for polymers," Electrophoresis, 25:203-213 (2004). doi pdf text

PDF version of Kirby, Reichmuth, Renzi, Shepodd, Wiedenman: Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements

Kirby BJ, Reichmuth DS, Renzi RF, Shepodd TJ, Wiedenman BJ
"Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements," Lab on a Chip 5:184-190 (2005). doi pdf text

PDF version of Reichmuth, Kirby: Effects of ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and reversed-phase HPLC separations

Reichmuth DS, Kirby BJ
"Effects of Ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and Reversed-Phase HPLC separations," Journal of Chromatography A, 1013:93-101 (2003). doi pdf text

PDF version of Reichmuth, Chirica, Kirby: Increasing the performance of high-pressure, high-efficiency electrokinetic micropumps using zwitterionic solute additives

Reichmuth DS, Chirica GS, Kirby BJ
"Increasing the Performance of High-Pressure, High-Efficiency Electrokinetic Micropumps Using Zwitterionic Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003). doi pdf text

PDF versino of Fintschenko, Kirby, Hasselbrink, Singh, Shepodd: Monolithic materials: miniature and microchip technologies

Fintschenko Y, Kirby BJ, Hasselbrink, Jr. EF, Singh AK, Shepodd TJ
"Monolithic Materials: Miniature and Microchip Technologies," in Monolithic Materials: Preparation, Properties, and Applications Elsevier, Amsterdam (2003). pdf

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

PDF version of Kirby, Shepodd, Hasselbrink: Voltage-addressable on/off microvalves for high-pressure microchip separations

Kirby BJ, Shepodd TJ, Hasselbrink, Jr. EF
"Voltage-Addressable On/Off Microvalves for High-Pressure Microchip Separations," Journal of Chromatography A 979:147-154 (2002). doi pdf

PDF version of Kirby, Hanson: Imaging of CO and CO2 using infrared planar laser-induced fluorescence

Kirby BJ, Hanson RK
"Imaging of CO and CO2 using infrared planar laser-induced fluorescence," Proceedings of the Combustion Institute, 28:253-259 (2000).

Kirby, Hanson: CO2 imaging with saturated planar laser-induced vibrational fluorescence

Kirby BJ, Hanson RK
"CO2 imaging with saturated planar laser-induced vibrational fluorescence," Applied Optics, 40:6136-6144 (2001). doi pdf

PDF version of Kirby, Hanson: Linear excitation schemes for IR PLIF imaging of CO and CO2

Kirby BJ, Hanson RK
"Linear excitation schemes for IR PLIF imaging of CO and CO2," Applied Optics, 41:1190-1201 (2002). doi pdf

PDF version of Kirby, Hanson: Planar laser-induced fluorescence imaging of carbon monoxide using vibrational (infrared) transitions

Kirby BJ, Hanson RK
"Planar laser-induced fluorescence imaging of carbon monoxide using vibrational (infrared) transitions,"Applied Physics B—Lasers and Optics 69:505-507 (1999). doi pdf

PDF version of Thurber, Grisch, Kirby, Votsmeier, Hanson: Measurements and modeling of acetone laser-induced fluorescence with implications for temperature-imaging diagnostics

Thurber MC, Grisch F, Kirby BJ, Votsmeier M, Hanson RK
"Measurements and modeling of acetone laser-induced fluorescence with implications for temperature-imaging diagnostics,"Applied Optics 37:4963-4978 (1998).

PDF version of Brusstar, Merte, Keller, Kirby: Effects of heater surface orientation on the critical heat flux.  I.  An experimental evaluation of models for subcooled pool boiling

Brusstar MJ, Merte Jr. H, Keller RB, Kirby BJ
"Effects of heater surface orientation on the critical heat flux--I. An experimental evaluation of models for subcooled pool boiling,"International Journal of Heat and Mass Transfer 40 4007-4019 (1997).

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News

Monday, August 13, 2012
Scientific American reports on blood tests for cancer

Scientific American recently reported on blood tests for cancer, including our GEDI device--see the report here.
 

Wednesday, August 01, 2012
Demystifying circulating tumor cells

See this article on circulating tumor cells in Genetic Engineering and Biotechnology News, featuring our GEDI microdevice among several CTC …
Read more...
 

Friday, June 29, 2012
Medical Device Daily reports on GEDI device

The GEDI device and related research was reported on in Medical Device Daily--see the writeup here.
 

Thursday, June 28, 2012
The Force is with us: GEDI chip sorts prostate cancer cells

Our work was recently reported on in the Cornell Chronicle--see the article here or see the video below: Embedded video from Cornell University …
Read more...
 

Monday, June 18, 2012
Rouillard reports on mechanical regulation of fibroblasts

Kirbylab alumnus Andrew Rouillard and his advisor Jeff Holmes recently reported on fibroblast migration and collagen remodeling in healing myocardial …
Read more...
 

Thursday, June 14, 2012
Presentan en NY avances para personalizar tratamientos contra cáncer

Para leer este artículo, haz clic aquí o aquí.
 

Friday, April 27, 2012
Cornell demonstrates functional characterization of circulating tumor cells

A team of Cornell-Ithaca and Weill-Cornell Medical College researchers reported today in PLoS ONE demonstration of functional characterization of …
Read more...
 

Saturday, March 31, 2012
Lannin wins NSF fellowship

Congratulations to Tim Lannin, who recently received an NSF fellowship.  Good work Tim!
 

Tuesday, February 21, 2012
Pratt wins CMM Young Investigator Award

We are excited to announce that Erica Pratt has won a Center for Microenvironment and Metastasis Young Investigator Award, which provided $25K direct …
Read more...
 

Tuesday, July 05, 2011
Polacheck reports on cancer cell migration in PNAS


Congrats to Kirbylab alumnus Bill Polacheck, whose first paper in Roger Kamm's lab just came out.  Good work, Bill!
 

Thursday, June 23, 2011
Barbati to chair international Gordon Research Seminar on Microfluidics

During 25-26 June 2011, Alex Barbati will serve as the Chair of the international Gordon Research Seminar on the Physics and Chemistry of …
Read more...
 

Wednesday, June 08, 2011
Announcing the 2011 Microfluidics GRC

We are pleased to announce the 2011 Microfluidics GRC!  Please click the link to see the workshop program and other details.
Click here for workshop program
 

Thursday, May 12, 2011
Kirbylab receives grant for genetic analysis of circulating tumor cells

Kirbylab received NCI support today for several genetic analyses of circulating tumor cells.  The work, in collaboration with Weill Cornell …
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Wednesday, April 27, 2011
Multi-institutional team chosen to probe cytoskeletal architecture in CTCs

The NIH-NCI Physical Sciences in Oncology Program has selected several multi-institutional teams for funding to probe heterogeneity in cancer systems.…
Read more...
 

Monday, April 04, 2011
Hawkins reports on automated characterization of Mycobacterium

Congratulations to Ben, Charlie, and Nitya, whose paper (click here) was published in Analytical Chemistry today.  Their work involves …
Read more...