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Electrokinetic Properties of Microfluidic Substrates
Funding: DOE, Lockheed Martin, Cornell, ACS-PRF
Among the unique properties of microfluidic devices is the ability to move liquids via electroosmosis. When the solid-liquid interface acquires a surface charge, an electrical double layer is formed as ions in the electrolyte solution align preferentially based on their charge. When this occurs, an electric field applied parallel to the wall will induce fluid flow.

Modeling and predicting the electrokinetic properties of microfluidic substrates that lead to electroosmosis is inherently difficult. The surface charges are a function of chemical reactions and adsorption/desorption processes, many of which are not fully understood. Further, the electrical double layer is often nanometers thick, and bulk fluid properties typically do not apply close to the wall, where the highest charge density (and therefore most of the action) resides.

Our work on the electrokinetic properties of microfluidic substrates includes (1) experimental characterization of interface properties, (2) chemical modification of interface properties, and (3) analytical and numerical modeling of double layer phenomena.

Archival Publications

HTML version of Kirby: Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices," Cambridge University Press, 2010.
click here for html version| Cambridge University Press

HTML page for Wilkes: Fluid Mechanics for Chemical Engineers with Microfluidics and CFD

Wilkes JO , with Birmingham SG, Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD," Prentice-Hall, 2005.
click here to go to text webpage

PDF version of Barbati, Kirby:
Electrokinetic Measurements of Thin Nafion Films

Barbati AC, Kirby BJ,
"Electrokinetic Measurements of Thin Nafion Films", Langmuir, 30:1985-1993, 2014. doi pdf

PDF version of Barbati, Kirby:
Force and Flux Relations for Flows of Ionic Solutions between
Parallel Plates with Porous and Charged Layers

Barbati AC, Kirby BJ,
"Force and Flux Relations for Flows of Ionic Solutions between Parallel Plates with Porous and Charged Layers", Physical Review E, 88:042408, 2013. doi pdf

Barbati AC, Kirby BJ,
"Surface conductivity in electrokinetic systems with porous and charged interfaces: Analytical approximations and numerical results", submitted, 2013.

PDF version of Barbati, Kirby:
Soft Diffuse Interfaces in Electrokinetics - Theory and experiment for transport in charged diffuse layers

Barbati AC, Kirby BJ,
"Soft Diffuse Interfaces in Electrokinetics - Theory and experiment for transport in charged diffuse layers", Soft Matter, 8:10598-10613, 2012. doi pdf

PDF version of Connelly Kondapalli Parker Kirby Baeumner: Micro total analysis system for virus detection:microfluidic pre-concentration coupled to liposome-based detection

Connelly JT, Kondapalli S, Skoupi M, Parker JSL, Kirby BJ, Baeumner AJ
"Micro total analysis system for virus detection:microfluidic pre-concentration coupled to liposome-based detection," Analytical and Bioanalytical Chemistry, Volume 402, Number 1, 315-323, 2012. doi pdf

PDF version of Kondapalli Connelly Baeumner Kirby: Integrated microfluidic preconcentrator and immunobiosensor

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"Integrated microfluidic preconcentrator and immunobiosensor," Microfluidics and Nanofluidics, Volume 11, Number 5, 537-544, 2011. doi pdf

PDF version of Tandon Kirby: Ambient Pressure Effects on the Electrokinetic Potential of Zeonor-Water Interfaces

Tandon VT, Kirby BJ
"Ambient Pressure Effects on the Electrokinetic Potential of Zeonor-Water Interfaces," Journal of Colloid and Interface Science, 361:381-387, 2011. doi pdf

PDF version of Tandon Kirby: Transient zeta potential measuremnts in hydrophobic topas microfluidics substrates

Tandon VT, Bhagavatula S, Kirby BJ
"Transient Zeta Potential Measurements in Hydrophobic, TOPAS Microfluidic Substrates," Electrophoresis 30(15) 2656-2667, 2009. doi pdf

PDF version of Tandon V Bhagavatula SK Nelson WC Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge

Tandon V, Bhagavatula SK, Nelson WC, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge", Electrophoresis 29(5):1092-1101, 2008. doi pdf

PDF version of Tandon V Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices 
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure

Tandon V, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 2. Slip and interfacial water structure", Electrophoresis 29(5):1102-1114, 2008. doi pdf

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 1. Theory, experimental techniques, and effects on separations

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 1. Theory, experimental techniques, and effects on separations," Electrophoresis, 25:187-202 (2004). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 2. Data for polymers

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 2. Data for polymers," Electrophoresis, 25:203-213 (2004). doi pdf text

PDF version of Reichmuth, Kirby: Effects of ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and reversed-phase HPLC separations

Reichmuth DS, Kirby BJ
"Effects of Ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and Reversed-Phase HPLC separations," Journal of Chromatography A, 1013:93-101 (2003). doi pdf text

PDF version of Reichmuth, Chirica, Kirby: Increasing the performance of high-pressure, high-efficiency electrokinetic micropumps using zwitterionic solute additives

Reichmuth DS, Chirica GS, Kirby BJ
"Increasing the Performance of High-Pressure, High-Efficiency Electrokinetic Micropumps Using Zwitterionic Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003). doi pdf text

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

Presentations and Other Publications
7 Nov 2012

Kirby BJ
"Electrokinetic and immunospecific characterization of cells for human health and energy applications", SUNY-Buffalo Chemical and Biomolecular Engineering Seminar Series, Buffalo, NY.

16-18 Jul 2012

Kirby BJ
ICREA Symposium on Nanofluidics, Colloids, and Membranes, Barcelona, Spain.

20-25 June 2010

Connelly JT, Kondapalli S, Skoupi M, Parker JSL, Kirby BJ, Baeumner AJ
"Electrochemical biosensor with integrated preconcentration module for the detection of enteric viruses," Gordon Research Conference on Bioanalytical Sensors, Colby-Sawyer College, New London, NH.

1-5 Nov 2009

Tandon V, Bhagavatula SK, Kirby BJ
"Disruption of long-term electrokinetic transients in pressure driven flow via a short-term application of an electric field", MicroTAS 2009, Jeju, Korea.

1-5 Nov 2009

Tandon V, Bhagavatula SK, Kirby BJ
"Disruption of long-term electrokinetic transients in pressure driven flow via a short-term application of an electric field ", MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.

30 Jan 2009

Kirby BJ
"Geometric micro- and mesopatterning for control of cell transport and microenvironemnt in microdevices and tissue-engineered scaffolds", Carnegie-Mellon Mechanical Engineering Seminar Series, Pittsburgh, PA.

12-16 Oct 2008

Tandon V, Bhagavatula SK, Kirby BJ
"Transient Electrokinetic Phenomena in Hydrophobic Microfluidic Devices," 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), San Diego, CA.

10 apr 2008

Kirby BJ
"Electrokinetic Tool of Cellular Screening in Plastic Microdevices: Interfacial Characterization and Engineering Design", Temple University Chemistry Department, Philadelphia, PA.

4 Mar 2008

Kirby BJ
"Micropatterning in injection-molded microdevices and engineered tissue scaffolds: the role of electrokinetic coupling", University of Illinois Mechancal Science and Engineering Department, Urbana, IL

4-9 Nov 2007

Tandon V, Bhagavatula SK, Nelson WC, Sharma AN, Kirby BJ
"Electrokinetic and scanned probe microscopy characterization of interfacial nanobubble phenomena in hydrophobic microfluidic devices", AIChE 2007, Salt Lake City, UT, November 2007.

7-12 Oct 2007.

Hawkins BG, Tandon V, Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial characterization and engineering design", Meeting of the Electrochemical Society, Washington, DC.

7-11 Oct 2007

Tandon V, Bhagavatula SK, Nelson WC, Sharma AN, Kirby BJ
"Electrokinetic and scanned probe microscopy characterization of interfacial nanobubble phenomena in hydrophobic microfluidic devices", MicroTAS 2007, Paris, France, October 2007.

15-20 Jul 2007

Tandon V, Bhagavatula SK, Nelson WC, Sharma AN, Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH.

10 May 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", University of Toronto Analytical Chemistry Seminar Series, Toronto, Canada.

24 Apr 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", Lafayette Bioengineering and Biomedicine Symposium, Easton, PA.

26 Feb 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Biological and Environmental Engineering Seminar Series, Cornell University, Ithaca, NY.

25 Jan 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Textiles and Apparel Seminar Series, Cornell University, Ithaca, NY.

6 Oct 2006

Kirby BJ
"Fabrication for design and control of micro/nanofluidic systems", University of Michigan Mechanical Engineering Seminar Series, Ann Arbor, MI.

21 Jun 2006

Kirby BJ
"Electrokinetics in fluid systems: Control of fields with multiscale geometric patterning", 2nd New York Complex Matter Workshop, Ithaca, NY.

12 Jan 2006

Kirby BJ
"Miniaturized devices for combinatorial chemistry and nanofluidic study", Sandia National Laboratories, Livermore, CA.

9 Dec 2005

Kirby BJ
Kodak Research Laboratories, Rochester, NY.

10 Nov 2005

Kirby BJ
Mechanical Engineering and Applied Mechanics Department, University of Pennsylvania, Philadelphia, PA.

27 Oct 2005

Kirby BJ
Dept. of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark.

18 Oct 2005

Kirby BJ
Nanobiotechnology Center, Cornell University, Ithaca, NY.

27 Sep 2005

Kirby BJ
Cornell Fluid Dynamics Seminar, Ithaca, NY.

25 July 2005

Kirby BJ
Gordon Research Conference on the Physics and Chemistry of Microfluidics, Oxford, UK.

10 Feb 2005

Kirby BJ
APS March Annual Meeting, San Francisco, CA.

10 Feb 2005

Kirby BJ
Johns Hopkins Mechanical Engineering Seminar Series, Baltimore, MD.

Oct 2001
PDF version of Kirby, Wheeler, Shepodd, Fruetel, Hasselbrink, Zare: A laser-polymerized thin film silica surface modification for suppression of cell adhesion and electroosmotic flow in microchannels

Kirby BJ, Wheeler AR, Shepodd TJ, Fruetel JA, Hasselbrink, Jr. EF, Zare RN
"A Laser-Polymerized Thin Film Silica Surface Modification for Suppression of Cell Adhesion and Electroosmotic Flow in Microchannels," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Oct 2001
PDF version of Wheeler, Morishima, Kirby, Leach, Zare: CATH.a neuron cell analysis on a chip with micellar electrokinetic chromatography

Wheeler AR, Morishima K, Kirby BJ, Leach A, Zare RN
"CATH.a Neuron Cell Analysis on a Chip With Micellar Electrokinetic Chromatography," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Thin spun Nafion which we are using to characterize interfacial properties of highly charged films.
Streaming potential device for characterizing interfacial properties of Nafion films.
Ellipsometry of Nafion films, whose interfacial properties we are characterizing with a focus on electrokinetic response.